Preimplantation genetic diagnosis of pericentric inversions.
نویسندگان
چکیده
Inversions are structural chromosome abnormalities that may be associated with infertility, multiple miscarriage and chromosomally unbalanced offspring. Preimplantation genetic diagnosis (PGD) with subtelomeric probes was used to select for transfer only those embryos that were normal or balanced for three pericentric inversions. In contrast to previous protocols the present procedure allows the detection of unbalanced embryos that might arise from U-recombination in the inverted region. Additionally, aneuploidy screening was carried out in two cases by a second round of fluorescent in situ hybridization (FISH) with centromeric probes. Of the three couples that underwent the procedure one became pregnant twice. The first pregnancy delivered a healthy and chromosomally normal baby and the second pregnancy is ongoing with triplets.
منابع مشابه
A positive correlation between crossing over within heterozygous pericentric inversions and reduced egg hatch of Drosophila females.
XTENSIVE chromosomal polymorphism, probably due to pericentric inverE sions, has been reported in animals as dissimilar as grasshoppers (WHITE 1958) and mice ( OHNO et al. 1966). Inversion polymorphism is also prevalent in natural populations of many Drosophila species, but rarely are the inversions pericentric. The infrequency with which pericentric as compared with paracentric inversions are ...
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عنوان ژورنال:
- Prenatal diagnosis
دوره 21 9 شماره
صفحات -
تاریخ انتشار 2001